The endogenous GABA bioactivity of camel, bovine, goat and human milks.

GABA orally administered has several beneficial effects on health, including the regulation of hyperglycaemic states in humans. Those effects are similar to the effects reported for camel milk (CMk); however, it is not known whether compounds with GABAergic activity are present in milk from camels or other species. W e determined CMk free - GABA concentration by LS/MS and its bioactivity on human GABA receptors. The relationship between GABA and taurine concentra tions suggests that whole came We found that camel and goat milks have significantly more bioavailable GABA than cow and human milks and are able to activate GABA ρ receptors. l milk may be more efficient to activate GABA ρ 1 receptors than goat milk. Because GABA ρ receptors are normally found in enteroendocrine cells in the lumen of the digestive tract, these results suggest that GABA in camel and goat milk may participate in GABA - modulated functions of enteroendocrine cells in the GI lumen.